بررسی سطح لیپیدها و لیپوپروتئین‌های سرم خون در بیماران مبتلا به دیابت ملیتوس تیپ 2 با گرفتگی عروق کرونر STUDY OF SERUM LIPID AND LIPOPROTEIN LEVELS IN PATIENTS WITH CORONARY ARTERY DISEASE AND TYPE 2 DIABETES MELLITUS

ABSTRACT Coronary artery disease (CAD) is the leading cause of death among non-insulin dependant diabetic (NIDDM) Patients. One of risk factor for CAD in dyslipidemia. In regards to high prevalence of NIDDM and CAD among our people, in the present study, levels of lipids and lipoproteins in two groups of patients, CAD+/NIDDM+ group and CAD+/NIDDM- group, were evaluated and compared. The study contained 50 NIDDM patients with CAD by coronary angiography (CAD+/NIDDM+ group) and 50 patients with CAD but without NIDDM (CAD+/NIDDM- group). The study also included a control group without CAD and NIDDM (CAD-/NIDDM- group)comprised 30 healthy subjects. The concentrations of cholesterol and triglyceride and HDL-c in serum were measured by an enzymatic colorimetric assay using an automated analyzer. Serum lipids and lipoproteins were not significantly different in CAD+/NIDDM+ group as compared to CAD+/NIDDM- group. Serum HDL-c was decreased in CAD+/NIDDM+ group compared to the healthy sabjects (P<0.01). We observed the significant increase in TC/HDL-c and LDL-c/HDL-c ratios in CAD+/NIDDM+ and CAD+/NIDDM- groups compared to healthy subjects. In conclusion, we have shown no significant differences in serum lipids and lipoproteins in diabetic patients with CAD compared to non-diabetic patients with CAD, therefor, dyslipidemia does not appear to be correlated with CAD in diabetic patients. However, serum levels of HDL-c and TC/HDL-c and LDL-c/HDL-c ratios in diabetic and non-diabetic patients with CAD were significantly different compared to those of healthy subjects. These results show the importance of these factors as markers for monitoring the progression of CAD.